Lwengo District is a district in Central Uganda. It is named after Lwengo, the largest town in the district and the location of the district headquarters.
Lwengo District is bordered by Sembabule District to the north, Bukomansimbi District to the northeast, Masaka District to the east, Rakai District to the south, and Lyantonde District to the west. Lwengo, the district headquarters, is located 45 kilometres (28 mi), by road, west of Masaka, the nearest large city. The coordinates of the district are:00 24S, 31 25E.
Lwengo District in one of the newest districts in Uganda. Created by Act of Parliament, the district became functional on 01 July 2010. Prior to that, it was part of Masaka District. Generally, the district is rural, with limited public services. Subsistence agriculture and livestock farming are the two main economic activities in Lwengo. There is no hospital in the district.
The 2002 Uganda national census estimated the population of Lwengo District at about 242,300. The exact population of the district as of December 2010 is not known.